Antibiotic potency of Straptomyces drozdowiczii on white Rattus norvegicus which is infected with Acinobacter baumanii

Acinobacter baumannii multi drug resistant (MDR) bacteria are recognized as one of the aerobic bacteria resistant to some antibiotics.. The aim of this study is to find appropriate doses of antibiotics used in white mice infected with MDR A baumanni; toxicity liver organ and histopathology of treate...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2019-11, Vol.347 (1), p.12052
Main Authors: Kawuri, R, Darmayasa, I B G, Gading, C
Format: Article
Language:English
Subjects:
Aerobic bacteria
Animals
Antibiotics
Bacteria
Blood
Ciprofloxacin
Damage
Drug resistance
Hepatocytes
Histopathology
Liver
Paraffin
Paraffins
Toxicity
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Summary:Acinobacter baumannii multi drug resistant (MDR) bacteria are recognized as one of the aerobic bacteria resistant to some antibiotics.. The aim of this study is to find appropriate doses of antibiotics used in white mice infected with MDR A baumanni; toxicity liver organ and histopathology of treated white mice. Mice was infected with A baumanii one day before treatment. Antibiotic Streptomyces drozdowiczii dose treatment with concentration 7%, 6%, 5%, 4% and control (without treatment) and positive control with ciprofloxacin.. Blood cuture is taken after 5 days to determine total bacteria A baumanii and liver funtion. Liver histopathology analysis is done by histological incisions with paraffin and staining methods. The results showed that % of live animals were antibiotic concentrations of 4% 5%, 6%, 7%, positive controls and negative controls, ie sequentially 40%, 100%, 100%, 100%, 100% and 100%. All animals did not show liver damage from SGOT and SGPT analyzes. Histopathological analysis showed liver cells in animals tried positive control, negative control and administration of 7% antibiotic showed normal liver cells, Conclusion; 7% antibiotic is the best by not damaging the liver and A baumanii bacteria is not present in the blood.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/347/1/012052