Study of the influence of anthropogenic factors on organism

The use of iron nanoparticles of various forms in industry continues to grow; therefore, there are risks of environmental damage and toxicity. The study was conducted on Wistar rats (n = 36). Nanoparticles of iron oxide and cobalt ferrite were injected once intraperitoneally at doses of 2 and 2.3 mg...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2021-01, Vol.624 (1), p.12187
Main Authors: Notova, S V, Kazakova, T V, Marshinskaia, O V, Kiyaeva, E V, Sheida, E V
Format: Article
Language:English
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Summary:The use of iron nanoparticles of various forms in industry continues to grow; therefore, there are risks of environmental damage and toxicity. The study was conducted on Wistar rats (n = 36). Nanoparticles of iron oxide and cobalt ferrite were injected once intraperitoneally at doses of 2 and 2.3 mg/kg (45 nm). On the 1st, 7th and 21st day of the experiment, the emotional and motor activities were assessed using the Open Field and Black and White Chamber tests. The results presented demonstrate that the liver and spleen are target organs that are able to accumulate nanoparticles; iron nanoparticles have a neurotropic effect and may have an anxiolytic effect. Despite the negative results obtained, the prospects of using nanoparticles cannot be denied. The use of a systematic and comprehensive approach to the assessment of risks and toxicity of nanomaterials will allow creating conditions to build a unified concept of nanosafety.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/624/1/012187