Design and simulation of a novel MEMS based microfluidic circulating tumor cell (CTC) detection system for a lab on a chip device

This paper proposes a novel microfluidic system for a lab on a chip device which includes three major systems: a microchannel, micromixer and a droplet generator. The novel system proposes electroosmotic fluid flow control combining droplet generation and immunocapturing based CTC separation. ANSYS...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2020-07, Vol.895 (1), p.12016
Main Authors: Suriyage, M P, Asanka, P V K, Cooray, T M G C S P, Liyanage, D L F M, Pushpakumara, R A N I, Hendavitharana, D K, Fernando, W W A T I, Sampath, W H P, Amarasinghe, Y W R
Format: Article
Language:English
Subjects:
Droplets
Flow control
Fluid dynamics
Fluid flow
Lab-on-a-chip
Microchannels
Microfluidics
Optimization
Parameters
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Summary:This paper proposes a novel microfluidic system for a lab on a chip device which includes three major systems: a microchannel, micromixer and a droplet generator. The novel system proposes electroosmotic fluid flow control combining droplet generation and immunocapturing based CTC separation. ANSYS Fluent is used to optimize the fluid flow parameters, droplet size and justify the mixing capability of the micromixer. COMSOL Multiphysics simulations justify the integration of the electroosmotic fluid flow control for precise generation of droplets and optimization of dimensional parameters of microchannels, followed by a fabrication method for the microfluidic system.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/895/1/012016