Apoptosis induced by paclitaxel-loaded copolymer PLA-TPGS in Hep-G2 cells

Paclitaxel is an important anticancer drug in clinical use for treatment of a variety of cancers. The clinical application of paclitaxel in cancer treatment is considerably limited due to its serious poor delivery characteristics. In this study paclitaxel-loaded copolymer poly(lactide)-d-α-tocophery...

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Bibliographic Details
Published in:Advances in natural sciences. Nanoscience and nanotechnology 2012-10, Vol.3 (4), p.45005
Main Authors: Nguyen, Hoai Nam, Tran Thi, Hong Ha, Quang, Duong Le, Thi, Toan Nguyen, Tran Thi, Nhu Hang, Le, Mai Huong, Ha, Phuong Thu
Format: Article
Language:English
Subjects:
apoptosis
paclitaxel nanoparticles
paclitaxel-loaded PLA-TPGS
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Summary:Paclitaxel is an important anticancer drug in clinical use for treatment of a variety of cancers. The clinical application of paclitaxel in cancer treatment is considerably limited due to its serious poor delivery characteristics. In this study paclitaxel-loaded copolymer poly(lactide)-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) nanoparticles were prepared by a modified solvent extraction/evaporation technique. The characteristics of the nanoparticles, such as surface morphology, size distribution, zeta potential, solubility and apoptosis were investigated in vitro. The obtained spherical nanoparticles were negatively charged with a zeta potential of about −18 mV with the size around 44 nm and a narrow size distribution. The ability of paclitaxel-loaded PLA-TPGS nanoparticles to induce apoptosis in human hepatocellular carcinoma cell line (Hep-G2) indicates the possibility of developing paclitaxel nanoparticles as a potential universal cancer chemotherapeutic agent.
ISSN:2043-6262
2043-6262
DOI:10.1088/2043-6262/3/4/045005