Curcumin as fluorescent probe for directly monitoring in vitro uptake of curcumin combined paclitaxel loaded PLA-TPGS nanoparticles

Theranostics, which is the combination of both therapeutic and diagnostic capacities in one dose, is a promising tool for both clinical application and research. Although there are many chromophores available for optical imaging, their applications are limited due to the photobleaching property or i...

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Bibliographic Details
Published in:Advances in natural sciences. Nanoscience and nanotechnology 2016-06, Vol.7 (2), p.25001
Main Authors: Nguyen, Hoai Nam, Ha, Phuong Thu, Nguyen, Anh Sao, Nguyen, Dac Tu, Do, Hai Doan, Thi, Quy Nguyen, Thi, My Nhung Hoang
Format: Article
Language:English
Subjects:
curcumin
drug delivery nanosystem
fluorescent probe
paclitaxel
theranostics
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Summary:Theranostics, which is the combination of both therapeutic and diagnostic capacities in one dose, is a promising tool for both clinical application and research. Although there are many chromophores available for optical imaging, their applications are limited due to the photobleaching property or intrinsic toxicity. Curcumin, a natural compound extracted from the rhizome of curcuma longa, is well known thanks to its bio-pharmaceutical activities and strong fluorescence as biocompatible probe for bio-imaging. In this study, we aimed to fabricate a system with dual functions: diagnostic and therapeutic, based on poly(lactide)-tocopheryl polyethylene glycol succinate (PLA-TPGS) micelles co-loaded curcumin (Cur) and paclitaxel (PTX). Two kinds of curcumin nanoparticle (NP) were fabricated and characterized by Fourier transform infrared spectroscopy, field emission scanning electron microscopy and dynamic light scattering methods. The cellular uptake and fluorescent activities of curcumin in these systems were also tested by bioassay studies, and were compared with paclitaxe-oregon. The results showed that (Cur + PTX)-PLA-TPGS NPs is a potential system for cancer theranostics.
ISSN:2043-6262
2043-6254
2043-6262
DOI:10.1088/2043-6262/7/2/025001