Development of multifunctional H2S-releasing gold nanoparticles for chronic wound treatment

Chronic wounds, characterized by prolonged inflammation, require new therapies to improve healing. Hydrogen sulfide (H2S), a key neurotransmitter, supports critical factors in wound healing but is often deficient in chronic wounds. Despite its potential, the toxicity of direct H2S delivery and the u...

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Published in:Advances in natural sciences. Nanoscience and nanotechnology 2024-12, Vol.15 (4), p.045006
Main Authors: Nguyen, Van Phong, Nguyen, Huyen Thanh Anh, Trang Le, Ngoc Thuy, Nguyen, Ngoc Hoi, Nguyen, Dai Hai, Tran, Dieu Linh
Format: Article
Language:English
Subjects:
Angiogenesis
Biocompatibility
Cell migration
Cell proliferation
Chloroauric acid
diallyl trisulfides
Endothelial cells
Gold
gold nanoparticles
Hydrogen sulfide
Nanoparticles
Toxicity
Wound healing
wound treatment
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Summary:Chronic wounds, characterized by prolonged inflammation, require new therapies to improve healing. Hydrogen sulfide (H2S), a key neurotransmitter, supports critical factors in wound healing but is often deficient in chronic wounds. Despite its potential, the toxicity of direct H2S delivery and the unsustainable release from current systems hinder its therapeutic use. This study introduces H2S-releasing gold nanoparticles synthesized by reducing chloroauric acid (HAuCl4) with diallyl trisulfides (DATS), a naturally derived H2S donor. These nanoparticles are hypothesized to be biocompatible and multifunctional, combining H2S release with the beneficial properties of gold. Results show that DATS does not impair H2S release, and higher DATS concentrations enhance H2S output. The sustained H2S release promotes endothelial cell proliferation, migration, and angiogenesis while retaining the antimicrobial properties of gold nanoparticles, making this material promising for chronic wound treatment.
ISSN:2043-6254
2043-6262
DOI:10.1088/2043-6262/ad7c23