Preparation of graphene oxide membrane-daptomycin/epidermal growth factor dressing and its effect on wound healing

Herein, a series of environmentally friendly dressings were specially fabricated from graphene oxide (GO) membrane (a high quality substrate with antibacterial function) and Daptomycin (antibacterial function)/Epidermal growth factor (EGF, wound healing function) for the purpose of antibacterial app...

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Bibliographic Details
Published in:Materials research express 2022-09, Vol.9 (9), p.95003
Main Authors: Zhou, Daijun, tian, Peng, Li, Dong, Li, Jianjun, Zhang, Tao
Format: Article
Language:English
Subjects:
Contact angle
daptomycin
EGF
Epidermal growth factor
Fourier transforms
Graphene
graphene oxide membrane
Growth factors
Infrared analysis
Membranes
Substrates
Wound healing
wound healing adhesive
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Summary:Herein, a series of environmentally friendly dressings were specially fabricated from graphene oxide (GO) membrane (a high quality substrate with antibacterial function) and Daptomycin (antibacterial function)/Epidermal growth factor (EGF, wound healing function) for the purpose of antibacterial applications. A performance comparison was designed by employing four dressing samples, including the neat GO membrane (Group A), GO membrane-Daptomycin (Group B), GO membrane-EGF (Group C), and GO membrane-Daptomycin/EGF (Group D). The results analyzed using Fourier transform infrared spectroscopy suggested that Daptomycin and EGF might be adhered to the GO membrane. The contact angle test showed that the hydrophilicity of material gradually increased from Group A to Group D. Groups B and D displayed similar in vitro antibacterial activities, better than those of Groups A and C (their antibacterial performances were similar to each other); all the four experimental groups outperformed the control group (P > 0.05). On the other hand, Groups C and D could promote the proliferation effectively within 1–7 days (P 
ISSN:2053-1591
2053-1591
DOI:10.1088/2053-1591/abe24a