Integration of metformin-loaded MIL-100(Fe) into hydrogel microneedles for prolonged regulation of blood glucose levels

The transdermal drug delivery based on microneedles (MNs) provides a suitable and painless self-administration for diabetic patients. In this work, the hydrogel-forming MNs were firstly fabricated using poly(vinyl alcohol) (PVA) and chitosan (CS) as matrix. A hypoglycemic drug, metformin (Met), had...

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Bibliographic Details
Published in:Biomedical physics & engineering express 2024-07, Vol.10 (4), p.45004
Main Authors: Feng, Mingjia, Li, Yan, Sun, Yanfang, Liu, Tianqi, Yunusov, Khaydar E, Jiang, Guohua
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
biomaterials
Blood Glucose - analysis
Chitosan - chemistry
Diabetes Mellitus, Experimental - drug therapy
Drug Delivery Systems
Drug Liberation
Hydrogels - chemistry
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacokinetics
hypoglycemic effect
Male
Metformin - administration & dosage
microneedles
microstructure
Needles
Polyvinyl Alcohol - chemistry
Rats
Rats, Sprague-Dawley
Skin - metabolism
transdermal delivery
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Summary:The transdermal drug delivery based on microneedles (MNs) provides a suitable and painless self-administration for diabetic patients. In this work, the hydrogel-forming MNs were firstly fabricated using poly(vinyl alcohol) (PVA) and chitosan (CS) as matrix. A hypoglycemic drug, metformin (Met), had been loaded into MIL-100(Fe). Then, both of free Met and Met-loaded MIL-100(Fe) were integrated into hydrogel-forming MNs for regulation of blood glucose levels (BGLs) on diabetic rats. After penetrated into the skin, the free Met could be firstly released from MNs. Due to the absorption of interstitial fluid and subsequent release of loaded Met from MIL-100(Fe), leading to a sustainable and long-term drug release behaviors. A notable hypoglycemic effect and low risk of hypoglycemia could be obtained on diabetic rat models . The as-fabricated hydrogel-forming MNs expected to become a new type of transdermal drug delivery platform for transdermal delivery of high-dose drugs to form a long-term hypoglycemic effect.
ISSN:2057-1976
2057-1976
DOI:10.1088/2057-1976/ad43f0