Minimum inhibitory but maximum non-hemolytic concentration of plasma-treated catheters coated with L. tridentata and O. vulgare extracts

Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts, but their hemocompatibility and thermal stability must be studied. Nosocomial bacteria have developed resistance to conventional antibiotics. Herein, the minimum inhibitory but non-hemolytic concent...

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Bibliographic Details
Published in:Plasma science & technology 2023-12, Vol.25 (12), p.125503
Main Authors: ALONSO-MONTEMAYOR, Francisco Javier, DÁVILA-MEDINA, Miriam Desirée, ZUGASTI-CRUZ, Alejandro, NARRO-CÉSPEDES, Rosa Idalia, NEIRA-VELÁZQUEZ, María Guadalupe, SÁENZ-GALINDO, Aidé, ALONSO-CAMPOS, Eduardo
Format: Article
Language:English
Subjects:
antibacterial activity
biocompatibility
blood-contact device
cold plasma
nosocomial bacteria
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Summary:Antibacterial extract-coated catheters are promising alternatives to their conventional counterparts, but their hemocompatibility and thermal stability must be studied. Nosocomial bacteria have developed resistance to conventional antibiotics. Herein, the minimum inhibitory but non-hemolytic concentration (MIC-NH) and the thermal stability of Larrea tridentata ( L. tridentata ) and Origanum vulgare ( O. vulgare ) extract-coated catheters were studied. Besides, plasma pretreatment was performed to enhance the extract adhesion. Briefly, the extract-coated catheters prevent Staphylococcus aureus colonization without causing hemolysis by using L. tridentata and O. vulgare extracts at MIC-NH (5000 and 2500 μ g ml −1 , respectively). Moreover, it has been discovered that the extract coating and plasma treatment improved the thermal stability and the extract adhesion, respectively. Thus, this study provides evidence of alternative antibacterial but non-hemolytic extract-coated catheters.
ISSN:1009-0630
2058-6272
DOI:10.1088/2058-6272/ace955