Development of Molecularly Imprinted poly(Phenol) Membrane Based Electrochemical Sensor for The Selective Determination of Guanine
This article describes the development of a simple, selective and sensitive molecularly imprinted polymer (MIP) based voltammetric sensor for guanine (Gua). The recognition element, MIP was fabricated by electropolymerization of the functional monomer phenol in presence of Gua onto the surface of a...
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Published in: | Journal of the Electrochemical Society 2022-03, Vol.169 (3), p.37517 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This article describes the development of a simple, selective and sensitive molecularly imprinted polymer (MIP) based voltammetric sensor for guanine (Gua). The recognition element, MIP was fabricated by electropolymerization of the functional monomer phenol in presence of Gua onto the surface of a
poly
(L- Glutamic acid) (
p
Glu) modified glassy carbon electrode (GCE). Extraction of the template molecules, Gua from the
poly
(phenol) layer was carried out using a solvent mixture of ethanol and 10% acetic acid at 1:1 (v/v) ratio. Various experimental parameters determining the performance of the sensor were optimized and under these conditions the proposed sensor responds linearly to the concentration of Gua in the range from 8.00 × 10
−5
M to 2.00 × 10
−5
M and 1.00 × 10
−5
M to 5.00 × 10
−7
M with the limit of detection as low as 8.00 × 10
−8
M. The sensor exhibits excellent selectivity, reproducibility and stability. It was successfully applied in synthetic physiological fluids in order to verify its practical utility. |
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ISSN: | 0013-4651 1945-7111 |
DOI: | 10.1149/1945-7111/ac5c9a |