Review—Novel Trends in the Determination of Pharmaceutical Compounds Commonly Found in Topical Treatments using Electrochemical Sensing Approaches

• Published in: Journal of the Electrochemical Society 2024-04, Vol.171 (4), p.47502
• Main Authors: Tuchiu, Bianca-Maria, Stefan-van Staden, Raluca-Ioana, van Staden, Jacobus (Koos) Frederick
• Format: Article
• Language: English
• Subjects: analgesic; antibiotic; electrochemical sensor; topical drug
• ISSN: 0013-4651; 1945-7111
• DOI: 10.1149/1945-7111/ad3a1e

Topical treatments rely on drugs that play a crucial role in addressing skin and mucous membrane disorders. Therefore, it is highly needed to utilize accurate analytical techniques that can determine the concentration of these chemicals in various sample matrices, including pharmaceuticals, food, and water. Currently, electrochemical sensors are predominantly used in specific fields such as biomedical, industrial, and environmental monitoring, while they have not yet been incorporated into the pharmaceutical manufacturing industry. However, electrochemical methods employing an expanding range of sensors provide a reliable, cost-effective, and efficient substitute for classical analytical methods. Their potential is highly favorable, offering possibilities for simultaneous determination, miniaturization, and real-time on-site monitoring. This work covers numerous sensors designed between 2020 and 2023 for the determination of topical drugs, highlighting their respective benefits and drawbacks while illuminating emerging trends. Moreover, it discusses the correlation between the used materials and the ease of manufacturing, to the achieved results, including dynamic range, detection limit, sensitivity, and selectivity. This work aims to serve as a valuable resource for researchers, engineers, and policymakers in the evolving field of electrochemical sensing by providing guidance and facilitating decision-making, which could lead to significant innovations in sensor technology.