Synergistic Effect of Auto-Activation and Small RNA Regulation on Gene Expression

Auto-activation and small ribonucleic acid （RNA）-mediated regulation are two important mechanisms in controlling gene expression. We study the synergistic effect of these two regulations on gene expression. It is found that under this combinatorial regulation, gene expression exhibits bistable behav...

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Bibliographic Details
Published in:Chinese physics letters 2010-09, Vol.27 (9), p.237-240
Main Author: 熊礼平 马余强 汤雷翰
Format: Article
Language:English
Subjects:
Feedback
协同效应
噪声强度
基因表达
小RNA
小分子RNA
小核糖核酸
调控机制
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Summary:Auto-activation and small ribonucleic acid （RNA）-mediated regulation are two important mechanisms in controlling gene expression. We study the synergistic effect of these two regulations on gene expression. It is found that under this combinatorial regulation, gene expression exhibits bistable behaviors at the transition regime, while each of these two regulations, if working solely, only leads to monostability. Within the stochastic framework, the base pairing strength between sRNA and mRNA plays an important role in controlling the transition time between on and off states. The noise strength of protein number in the off state approaches 1 and is smaller than that in the on state. The noise strength also depends on which parameters, the feedback strength or the synthesis rate of small RNA, are tuned in switching the new insight into gene-regulation mechanism and can be gene expression on and off. Our findings may provide applied in synthetic biology.
ISSN:0256-307X
1741-3540
DOI:10.1088/0256-307X/27/9/098701