Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography

Photoacoustic tomography (PAT) is a rapidly emerging non-invasive imaging technology that integrates the merits of high optical contrast with high ultrasound resolution. The ability to quantitatively and non-invasively image nanoparticles has important implications for the development of nanoparticl...

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Bibliographic Details
Published in:Nanotechnology 2009-09, Vol.20 (39), p.395102-395102
Main Authors: Zhang, Q, Iwakuma, N, Sharma, P, Moudgil, B M, Wu, C, McNeill, J, Jiang, H, Grobmyer, S R
Format: Article
Language:English
Subjects:
Acoustics
Animals
Biomedical materials
Contrast Media - chemistry
Gold
Gold - chemistry
Hypodermoclysis
In vivo testing
In vivo tests
Metal Nanoparticles - chemistry
Mice
Mice, Inbred C57BL
Nanoparticles
Neoplasm Transplantation
Neoplasms - diagnosis
Neoplasms - pathology
Particle Size
PAT
Phantoms, Imaging
Signal Processing, Computer-Assisted
Surgical implants
Tomography - methods
Tumors
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Summary:Photoacoustic tomography (PAT) is a rapidly emerging non-invasive imaging technology that integrates the merits of high optical contrast with high ultrasound resolution. The ability to quantitatively and non-invasively image nanoparticles has important implications for the development of nanoparticles as in vivo cancer diagnostic and therapeutic agents. In this study, the ability of systemically administered poly(ethylene glycol)-coated (PEGylated) gold nanoparticles as a contrast agent for in vivo tumor imaging with PAT has been evaluated. We demonstrate that gold nanoparticles (20 and 50 nm) have high photoacoustic contrast as compared to mouse tissue ex vivo. Gold nanoparticles can be visualized in mice in vivo following subcutaneous administration using PAT. Following intravenous administration of PEGylated gold nanoparticles to tumor-bearing mice, accumulation of gold nanoparticles in tumors can be effectively imaged with PAT. With gold nanoparticles as a contrast agent, PAT has important potential applications in the image guided therapy of superficial tumors such as breast cancer, melanoma and Merkel cell carcinoma.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/20/39/395102