Systematic computational prediction of protein interaction networks

Determining the network of physical protein associations is an important first step in developing mechanistic evidence for elucidating biological pathways. Despite rapid advances in the field of high throughput experiments to determine protein interactions, the majority of associations remain unknow...

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Bibliographic Details
Published in:Physical biology 2011-06, Vol.8 (3), p.035008-035008
Main Authors: Lees, J G, Heriche, J K, Morilla, I, Ranea, J A, Orengo, C A
Format: Article
Language:English
Subjects:
Algorithms
Computational Biology - methods
Computer Simulation
Humans
Models, Molecular
Protein Conformation
Protein Interaction Mapping - methods
Protein Interaction Maps
Proteins - chemistry
Proteins - metabolism
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Summary:Determining the network of physical protein associations is an important first step in developing mechanistic evidence for elucidating biological pathways. Despite rapid advances in the field of high throughput experiments to determine protein interactions, the majority of associations remain unknown. Here we describe computational methods for significantly expanding protein association networks. We describe methods for integrating multiple independent sources of evidence to obtain higher quality predictions and we compare the major publicly available resources available for experimentalists to use.
ISSN:1478-3975
1478-3975
DOI:10.1088/1478-3975/8/3/035008