Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet

Purpose - The purpose of this paper is to report on the anti-cholesterol activities of Ganoderma lucidum on Sprague-Dawley white rats.Design methodology approach - Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for a per...

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Bibliographic Details
Published in:Nutrition and food science 2008-05, Vol.38 (3), p.229-238
Main Authors: Tong, Chow-Chin, Choong, Yew-Keong, Mohamed, Suhaila, Mohamed Mustapha, Noordin, Aini Umar, Nor
Format: Article
Language:English
Subjects:
Alternative medicines
Cholesterol
Diet
Lipids
Malaysia
Nutrition
Rodents
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Summary:Purpose - The purpose of this paper is to report on the anti-cholesterol activities of Ganoderma lucidum on Sprague-Dawley white rats.Design methodology approach - Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for a period of six months. At regular intervals, blood samples were taken and analysed for the total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C) levels.Findings - Administration of hyperlipidemia diet in rats fed with 1 per cent cholesterol diet caused an increase in the TC, TG, as well as LDL-C level as compared to the control. A decrease of 23.6 per cent in the HDL-C level was also noted. However, supplementation of the feed with G. lucidum (0.1 per cent) in rats decreased the TC, TG and LDL-C level significantly (P 
ISSN:0034-6659
1758-6917
DOI:10.1108/00346650810871911