Chain ordering of hybrid lipids can stabilize domains in saturated/hybrid/cholesterol lipid membranes

We use a liquid-crystal model to predict that hybrid lipids (lipids that have one saturated and one unsaturated tail) can stabilize line interfaces between domains in mixed membranes of saturated lipids, hybrid lipids, and cholesterol (SHC membranes). The model predicts the phase separation of SHC m...

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Bibliographic Details
Published in:Europhysics letters 2010-07, Vol.91 (2), p.28002
Main Authors: Yamamoto, T, Brewster, R, Safran, S. A
Format: Article
Language:English
Subjects:
64.75.Yz
82.70.Uv
87.16.D
Chains
Cholesterol
Line interfaces
Lipids
Mathematical models
Membranes
Phase separation
Unsaturated
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Summary:We use a liquid-crystal model to predict that hybrid lipids (lipids that have one saturated and one unsaturated tail) can stabilize line interfaces between domains in mixed membranes of saturated lipids, hybrid lipids, and cholesterol (SHC membranes). The model predicts the phase separation of SHC membranes with both parabolic and loop binodals depending on the cholesterol concentration, modeled via an effective pressure. In some cases, the hybrid lipids can reduce the line tension to zero in SHC membranes at temperatures that approach the critical temperature as the pressure is increased. The differences in the hybrid saturated tail conformational order in bulk and at the interface are responsible for the reduction of the line tension.
ISSN:0295-5075
1286-4854
DOI:10.1209/0295-5075/91/28002