Brief Communication: Hyperplasia of Rat Mammary Gland In Vitro

Rat mammary gland explants placed in organ culture underwent intraductal hyperplasia in the presence of insulin. The hyperplasia reached its maximum at about 2 weeks of culture and exhibited several morphologic variations. By ultrastructural criteria, it was shown that the proliferating cell was der...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1975-01, Vol.54 (1), p.235-240
Main Authors: Palekar, Lalita, Waldo, E. Daimont, Seidman, Irving
Format: Article
Language:English
Online Access:Get full text
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Summary:Rat mammary gland explants placed in organ culture underwent intraductal hyperplasia in the presence of insulin. The hyperplasia reached its maximum at about 2 weeks of culture and exhibited several morphologic variations. By ultrastructural criteria, it was shown that the proliferating cell was derived from the epithelial rather than the myoepithelial component of the ductal lining cells. Testosterone, added at the beginning of the experiment, partially inhibited the hyperplastic process.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/54.1.235