The nucleotide sequence of the yeast PHO5gene: a putative precursor of repressible acid phosphatase contains a signal peptide

The nucleotide sequence of the PH05 gene of the yeast, Saccharomyces cerevisiae, which encodes repressible acid phosphatase (APase) was determined. Comparison of N‐terminal amino acid sequence deduced from the nucleotide sequence with that of the purified repressible APase revealed the existence of...

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Bibliographic Details
Published in:Nucleic acids research 1983-03, Vol.11 (6), p.1657-1672
Main Authors: Arima, Kenji, Oshima, Takehiro, Kubota, Ichiro, Nakamura, Norihisa, Mizunaga, Takemitsu, Toh–e, Akio
Format: Article
Language:English
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Summary:The nucleotide sequence of the PH05 gene of the yeast, Saccharomyces cerevisiae, which encodes repressible acid phosphatase (APase) was determined. Comparison of N‐terminal amino acid sequence deduced from the nucleotide sequence with that of the purified repressible APase revealed the existence of a putative signal peptide in the precursor protein. The signal peptide was shown to contain 17 amino acid residues and its structural features were quite similar to those of higher eukaryotic and prokaryotlc signal peptides. The nucleotide sequence of 5′ and 3′ noncoding flanking regions of the PH05 gene are also discussed.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/11.6.1657