Vitamin D Receptor Gene Polymorphisms and Susceptibility to Mycobactevium malmoense Pulmonary Disease

Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense p...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2000-06, Vol.181 (6), p.2099-2102
Main Authors: Gelder, Colin M., Hart, Keith W., Williams, O. Martin, Lyons, Elizabeth, Welsh, Kenneth I., Campbell, Ian A., Marshall, Sara E.
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apa1 A (P = .03; Fisher's exact test), TaqI t (P = .04), and the At VDR haplotype (P = .04), and they displayed a decreased prevalence of FokI f (P = .04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P = .001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.
ISSN:0022-1899
1537-6613
DOI:10.1086/315489