Occupational induction of hypersensitivity after an accidental exposure to chloromethylisothiazolinone and methylisothiazolinone (CMI/MI) in an industrial worker

A process worker in a paper chemical plant developed an immediate local dermal irritation and delayed bullous dermatitis due to induction of hypersensitivity following an accidental exposure to chloromethylisothiazolinone and methylisothiazolinone (CMI/MI) biocide. Contact allergy to the isothiazoli...

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Bibliographic Details
Published in:Occupational Medicine 1999, Vol.49 (1), p.51-53
Main Authors: Kujala, V., Niinimäki, A.
Format: Report
Language:English
Subjects:
Allergic contact dermatitis
biocide
chemical industry
chloromethylisothiazolinone (CAS 26172-55-4)
methylisothiazolinone (CAS 2682-20-4)
occupational exposure
patch test
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Summary:A process worker in a paper chemical plant developed an immediate local dermal irritation and delayed bullous dermatitis due to induction of hypersensitivity following an accidental exposure to chloromethylisothiazolinone and methylisothiazolinone (CMI/MI) biocide. Contact allergy to the isothiazolinone mixture was confirmed by skin patch testing. The dermatitis healed in four weeks, and the worker was advised to avoid all CMI/MI containing products. In a one-year follow-up he did not present with any further skin symptoms. Preventive measures are important for avoiding induction of hypersensitivity to concentrated CMI/MI solutions in industrial workers.
ISSN:0962-7480
1471-8405
DOI:10.1093/occmed/49.1.51