Renal effects of maintenance low-dose cyclosporin A treatment in psoriasis

The renal effects of low-dose cyclosporin A (CsA) treatment in severe psoriasis was investigated in 10 patients treated with a mean CsA dose of 3.23 (range 1.94–4.10) mg/kg/day for 12 months. The psoriasis area and severity index was reduced by 63–76%. Ambulatory GFR (iothalamate-125I) ERPF (hippura...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1994, Vol.9 (10), p.1462-1467
Main Authors: Svarstad, E., Helland, S., Morken, T., Bostad, L., Myking, A., Iversen, B. M., Ofstad, J.
Format: Article
Language:English
Subjects:
ambulatory position
cyclosporin A
GFR
psoriasis
renal biopsy
renal haemodynamics
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Summary:The renal effects of low-dose cyclosporin A (CsA) treatment in severe psoriasis was investigated in 10 patients treated with a mean CsA dose of 3.23 (range 1.94–4.10) mg/kg/day for 12 months. The psoriasis area and severity index was reduced by 63–76%. Ambulatory GFR (iothalamate-125I) ERPF (hippuran-131), RVR and MAP were examined at 3-months intervals. A control renal biopsy was performed shortly before treatment start and a second biopsy was taken after 12 months of therapy. GFR was slightly but significantly reduced after 6 and 9 months; after 12 months the decrease was not significant (121.0±7.6 versus 115.2±7.8 ml/min/l.73M P>0.10). After 12 months serum creatinine increased from 82±4 to 94±7 μmol/litre (P
ISSN:0931-0509
1460-2385
DOI:10.1093/oxfordjournals.ndt.a092674