Tolerance Induced by Parity in Mice Incompatible at the H-2 Locus

• Published in: JNCI : Journal of the National Cancer Institute 1961-01, Vol.27 (2), p.409-413
• Main Authors: Breyere, Edward J., Barrett, Morris K.
• Format: Article
• Language: English
• ISSN: 0027-8874; 1460-2105
• DOI: 10.1093/jnci/27.2.409

BALB/c (H-2d) female mice were divided into 3 groups and mated to males of the following strains to produce from 1 to 8 Utters: C3H (H-2k), DBA/2 (H-2d), and BALB/c. A fourth group was retained as virgins. After the parous females had their last litter, all 4 groups were challenged with plasma-cell tumor SS (70429), of C3H origin. The tumor grew in 59 percent of females parous by C3H males, in less than 1 percent of those parous by BALB/c males, and in none of the others. These findings are presented as evidence that tolerance in an apparently H-2 incompatible system can be induced by strain-specific matings. As in previous studies, tolerance appeared to increase with multiparity. Approximately half the tumors in specifically parous females grew in the form of a ring, a phenomenon apparently peculiar to this situation.