Effect of magnesium sulphate in patients with unstable angina

Aim Administration of intravenous magnesium sulphate has been shown to be protective during acute myocardial ischaemia and it may therefore have beneficial effects in unstable angina. The purpose of this study was to assess the effects of a 24-h infusion of magnesium in patients with unstable angina...

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Bibliographic Details
Published in:European heart journal 1997-08, Vol.18 (8), p.1269-1277
Main Authors: Redwood, S. R., Bashir, Y., Huang, J., Leatham, E. W., Kaski, J.-C., Camm, A. J.
Format: Article
Language:English
Subjects:
catecholamines
ischaemia
Magnesium
unstable angina
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Summary:Aim Administration of intravenous magnesium sulphate has been shown to be protective during acute myocardial ischaemia and it may therefore have beneficial effects in unstable angina. The purpose of this study was to assess the effects of a 24-h infusion of magnesium in patients with unstable angina. Methods and results Patients who presented with unstable angina with electrocardiographic changes were randomized to receive a 24-h intravenous infusion of magnesium or placebo within 12 h of admission. The primary endpoint was myocardial ischaemia, as assessed by 48 h Holter monitoring. Resting 12-lead ECGs, creatine kinase-MB release and urinary catecholamines were also assessed. Patients were followed for 1 month. Thirty-one patients received magnesium sulphate and 31 placebo. Baseline characteristics and extent of coronary disease were similar in both groups. On 48 h Holter monitoring, 14 patients (50%) had transient ST segment shifts in the magnesium group vs 12 patients (46%) in the placebo group. However, there were fewer ischaemic episodes in the magnesium group (51 vs 101, P
ISSN:0195-668X
1522-9645
DOI:10.1093/oxfordjournals.eurheartj.a015438