Effect of Leupeptin, a Protease Inhibitor, on Induction of BladderTumors in Rats by N-Butyl-N- (4-hydroxybutyl ) nitrosamine

Leupeptin, isolated from Actinomycetes, is a potent and specific inhibitor of proteases. We found that the administration of leupeptin enhanced the size of urinary bladder tumors induced in rats by the oral administration of N-butyl-N( 4-hydroxybutyl)nitrosamine (BBN). BBN was given as a 0.05% solut...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1976-02, Vol.56 (2), p.433-435
Main Authors: Kakizoe, Tadao, Takayasu, Hisao, Kawachi, Takashi, Sugimura, Takashi, Takeuchi, Tomio, Umezawa, Hamao
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Leupeptin, isolated from Actinomycetes, is a potent and specific inhibitor of proteases. We found that the administration of leupeptin enhanced the size of urinary bladder tumors induced in rats by the oral administration of N-butyl-N( 4-hydroxybutyl)nitrosamine (BBN). BBN was given as a 0.05% solution in the drinking water for 6 weeks, and then animals were fed a diet with or without 0.1% leupeptin for 30 weeks. The average weight of the bladders with tumors in rats fed a leupeptin diet was about eight times that of rats on a diet without leupeptin, though the incidences and average numbers of tumors in the bladders were similar in the two group.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/56.2.433