Prolonged Survival of Skin and Tumor Allografts in Mice on High-Fat Diets: Brief Communication

The cancer-promoting effect of fat-enriched diets on mice has been known for several years. We investigated the effect of this type of diet supplemented with corn oil (200-400 ng/mouse daily), on two allograft models in the mouse, to determine whether an immunologic phenomenon occurred. Control mice...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1977-01, Vol.59 (2), p.459-461
Main Authors: Santiago-Delpín, Eduardo A., Szepsenwol, Josel
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cancer-promoting effect of fat-enriched diets on mice has been known for several years. We investigated the effect of this type of diet supplemented with corn oil (200-400 ng/mouse daily), on two allograft models in the mouse, to determine whether an immunologic phenomenon occurred. Control mice were fed a standard diet. Skin grafts transplanted from DBA/2J mice to BALB/c mice and from C57BL/6J mice to C57BR mice survived significantly longer on recipients fed fat-enriched diets than on those fed the control diet. Similarly, allogeneic tumor grafts (6C3HED on C57BR and BALB/c mice, and dbrB on BALB/c mice) survived longer on groups fed the experimental diet.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/59.2.459