Organophosphonate Functionalized Gd@C82 as a Magnetic Resonance Imaging Contrast Agent

A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM−1 s−1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM−1 s−1) a...

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Bibliographic Details
Published in:Chemistry of materials 2008-03, Vol.20 (6), p.2106-2109
Main Authors: Shu, Chun-Ying, Wang, Chun-Ru, Zhang, Jian-Fei, Gibson, Harry W, Dorn, Harry C, Corwin, Frank D, Fatouros, Panos P, Dennis, T. John S
Format: Article
Language:English
Subjects:
Bio- (and Biomimetic) Materials
Carbon Materials
Characterization of Materials
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Summary:A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM−1 s−1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM−1 s−1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C82 (16.0 mM−1 s−1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.
ISSN:0897-4756
1520-5002
DOI:10.1021/cm7023982