The role of glial cells in synaptic function

Glial cells represent the most abundant cell population in the central nervous system and for years they have been thought to provide just structural and trophic support to neurons. Recently, several studies were performed, leading to the identification of an active interaction between glia and neur...

Full description

Saved in:
Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 1999-02, Vol.354 (1381), p.403-409
Main Authors: Bacci, Alberto, Verderio, Claudia, Pravettoni, Elena, Matteoli, Michela
Format: Article
Language:English
Subjects:
Amino acid transport system XAG
Animals
Astrocytes
Astrocytes - physiology
Biological Transport, Active
Brain
Calcium
Calcium Signaling - physiology
Glia-Neuron Interaction
Glutamic Acid - physiology
Long term depression
Models, Neurological
Nervous System - growth & development
Neuroglia
Neuroglia - physiology
Neuron Development and Interactions
Neuronal Plasticity - physiology
Neurons
Neurons - physiology
Physiological regulation
Synapses
Synapses - physiology
Synaptic Transmission
Synaptogenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glial cells represent the most abundant cell population in the central nervous system and for years they have been thought to provide just structural and trophic support to neurons. Recently, several studies were performed, leading to the identification of an active interaction between glia and neurons. This paper focuses on the role played by glial cells at the level of the synapse, reviewing recent data defining how glia is determinant in synaptogenesis, in the modulation of fully working synaptic contacts and in synaptic plasticity.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.1999.0393