Autoantibodies to $\beta _{2}$-Adrenergic Receptors: A Possible Cause of Adrenergic Hyporesponsiveness in Allergic Rhinitis and Asthma

Autoantibodies to $\beta _{2}$-adrenergic receptors have been identified in the serum of one patient with allergic rhinitis (``hay fever'') and two patients with asthma. The antibodies precipitate solubilized dog lung $\beta $ receptors in an indirect immunoprecipitation assay and inhibit...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1980-03, Vol.207 (4437), p.1361-1363
Main Authors: Venter, J. Craig, Fraser, Claire M., Harrison, Len C.
Format: Article
Language:English
Subjects:
Allergies
Antibodies
Asthma
Autoantibodies
Canines
Diabetes
Ligands
Lungs
Receptors
Rhinitis
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Summary:Autoantibodies to $\beta _{2}$-adrenergic receptors have been identified in the serum of one patient with allergic rhinitis (``hay fever'') and two patients with asthma. The antibodies precipitate solubilized dog lung $\beta $ receptors in an indirect immunoprecipitation assay and inhibit the specific binding of iodine-125-labeled iodohydroxybenzylpindolol to membrane-associated receptors from dog lung, calf lung, and human placenta. Ligand binding to canine heart $\beta _{1}$ receptors is not affected by the antibodies.
ISSN:0036-8075
1095-9203