Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing

Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared t...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-01, Vol.211 (4477), p.80-82
Main Authors: Adams, Perrie M., Fabricant, Jill D., Legator, Marvin S.
Format: Article
Language:English
Subjects:
Air forces
Body weight
Cliffs
Female animals
Litter size
Male animals
Medical genetics
Pups
Scalp
Swimming
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.
ISSN:0036-8075
1095-9203