Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing

Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared t...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-01, Vol.211 (4477), p.80-82
Main Authors: Adams, Perrie M., Fabricant, Jill D., Legator, Marvin S.
Format: Article
Language:English
Subjects:
Air forces
Body weight
Cliffs
Female animals
Litter size
Male animals
Medical genetics
Pups
Scalp
Swimming
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 82
container_issue 4477
container_start_page 80
container_title Science (American Association for the Advancement of Science)
container_volume 211
creator Adams, Perrie M.
Fabricant, Jill D.
Legator, Marvin S.
description Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.
format article
fullrecord <record><control><sourceid>jstor</sourceid><recordid>TN_cdi_jstor_primary_1685543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1685543</jstor_id><sourcerecordid>1685543</sourcerecordid><originalsourceid>FETCH-jstor_primary_16855433</originalsourceid><addsrcrecordid>eNqFybsOgjAUANDGaCI-_sDhDqwkxYrCKoI6604qXKAEWtJWE2L8dxncnc5wJsTxaRR40ZayKXEoZXsvpIdgThbGNJSOFzGHVPGQt6qvlelr3okCvassnjkWcOtRd9yqCqXIISlLzK2BE9rRsYUEWyOkbvb2Py6cUaLmVigJjwGOWPOXUJq3cEdjhaxWZFby1uD655Js0uQeX7zGWKWzXouO6yHz92EQ7Bj7018dokOk</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing</title><source>Science Online科学在线</source><creator>Adams, Perrie M. ; Fabricant, Jill D. ; Legator, Marvin S.</creator><creatorcontrib>Adams, Perrie M. ; Fabricant, Jill D. ; Legator, Marvin S.</creatorcontrib><description>Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><language>eng</language><publisher>The American Association for the Advancement of Science</publisher><subject>Air forces ; Body weight ; Cliffs ; Female animals ; Litter size ; Male animals ; Medical genetics ; Pups ; Scalp ; Swimming</subject><ispartof>Science (American Association for the Advancement of Science), 1981-01, Vol.211 (4477), p.80-82</ispartof><rights>Copyright 1980 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Adams, Perrie M.</creatorcontrib><creatorcontrib>Fabricant, Jill D.</creatorcontrib><creatorcontrib>Legator, Marvin S.</creatorcontrib><title>Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing</title><title>Science (American Association for the Advancement of Science)</title><description>Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.</description><subject>Air forces</subject><subject>Body weight</subject><subject>Cliffs</subject><subject>Female animals</subject><subject>Litter size</subject><subject>Male animals</subject><subject>Medical genetics</subject><subject>Pups</subject><subject>Scalp</subject><subject>Swimming</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFybsOgjAUANDGaCI-_sDhDqwkxYrCKoI6604qXKAEWtJWE2L8dxncnc5wJsTxaRR40ZayKXEoZXsvpIdgThbGNJSOFzGHVPGQt6qvlelr3okCvassnjkWcOtRd9yqCqXIISlLzK2BE9rRsYUEWyOkbvb2Py6cUaLmVigJjwGOWPOXUJq3cEdjhaxWZFby1uD655Js0uQeX7zGWKWzXouO6yHz92EQ7Bj7018dokOk</recordid><startdate>19810102</startdate><enddate>19810102</enddate><creator>Adams, Perrie M.</creator><creator>Fabricant, Jill D.</creator><creator>Legator, Marvin S.</creator><general>The American Association for the Advancement of Science</general><scope/></search><sort><creationdate>19810102</creationdate><title>Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing</title><author>Adams, Perrie M. ; Fabricant, Jill D. ; Legator, Marvin S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-jstor_primary_16855433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Air forces</topic><topic>Body weight</topic><topic>Cliffs</topic><topic>Female animals</topic><topic>Litter size</topic><topic>Male animals</topic><topic>Medical genetics</topic><topic>Pups</topic><topic>Scalp</topic><topic>Swimming</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adams, Perrie M.</creatorcontrib><creatorcontrib>Fabricant, Jill D.</creatorcontrib><creatorcontrib>Legator, Marvin S.</creatorcontrib><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adams, Perrie M.</au><au>Fabricant, Jill D.</au><au>Legator, Marvin S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><date>1981-01-02</date><risdate>1981</risdate><volume>211</volume><issue>4477</issue><spage>80</spage><epage>82</epage><pages>80-82</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F$_{1}$ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.</abstract><pub>The American Association for the Advancement of Science</pub></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1981-01, Vol.211 (4477), p.80-82
issn 0036-8075
1095-9203
language eng
recordid cdi_jstor_primary_1685543
source Science Online科学在线
subjects Air forces
Body weight
Cliffs
Female animals
Litter size
Male animals
Medical genetics
Pups
Scalp
Swimming
title Cyclophosphamide-Induced Spermatogenic Effects Detected in the F$_{1}$ Generation by Behavioral Testing
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T02%3A28%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cyclophosphamide-Induced%20Spermatogenic%20Effects%20Detected%20in%20the%20F$_%7B1%7D$%20Generation%20by%20Behavioral%20Testing&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Adams,%20Perrie%20M.&rft.date=1981-01-02&rft.volume=211&rft.issue=4477&rft.spage=80&rft.epage=82&rft.pages=80-82&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/&rft_dat=%3Cjstor%3E1685543%3C/jstor%3E%3Cgrp_id%3Ecdi_FETCH-jstor_primary_16855433%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_jstor_id=1685543&rfr_iscdi=true