Elevated Salivary and Synovial Fluid $\beta _{2}$-Microglobulin in Sjogren's Syndrome and Rheumatoid Arthritis

$\beta _{2}$-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of $\beta _{2}$-microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, auto...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1975-03, Vol.187 (4182), p.1196-1198
Main Authors: Talal, Norman, Grey, Howard M., Zvaifler, Nathan, Michalski, Joseph P., Daniels, Troy E.
Format: Article
Language:English
Subjects:
B lymphocytes
Dry eye syndromes
Flow velocity
Lymphocytes
Phosphates
Phosphorylation
Rheumatoid arthritis
Saliva
Sjogrens syndrome
Synovial fluid
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Summary:$\beta _{2}$-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of $\beta _{2}$-microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, autoimmune inflammatory diseases that attack and destroy the salivary glands and articular tissues, respectively. Elevated $\beta _{2}$-microglobulin concentrations decreased in the saliva of two patients who simultaneously showed a clinical response to systemic treatment. Measurement of $\beta _{2}$-microglobulin in inflammatory fluids may offer a simple method of quantifying local activity in autoimmune states.
ISSN:0036-8075
1095-9203