Elevated Salivary and Synovial Fluid $\beta _{2}$-Microglobulin in Sjogren's Syndrome and Rheumatoid Arthritis

$\beta _{2}$-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of $\beta _{2}$-microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, auto...

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Published in:Science (American Association for the Advancement of Science) 1975-03, Vol.187 (4182), p.1196-1198
Main Authors: Talal, Norman, Grey, Howard M., Zvaifler, Nathan, Michalski, Joseph P., Daniels, Troy E.
Format: Article
Language:English
Subjects:
B lymphocytes
Dry eye syndromes
Flow velocity
Lymphocytes
Phosphates
Phosphorylation
Rheumatoid arthritis
Saliva
Sjogrens syndrome
Synovial fluid
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container_end_page 1198
container_issue 4182
container_start_page 1196
container_title Science (American Association for the Advancement of Science)
container_volume 187
creator Talal, Norman
Grey, Howard M.
Zvaifler, Nathan
Michalski, Joseph P.
Daniels, Troy E.
description $\beta _{2}$-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of $\beta _{2}$-microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, autoimmune inflammatory diseases that attack and destroy the salivary glands and articular tissues, respectively. Elevated $\beta _{2}$-microglobulin concentrations decreased in the saliva of two patients who simultaneously showed a clinical response to systemic treatment. Measurement of $\beta _{2}$-microglobulin in inflammatory fluids may offer a simple method of quantifying local activity in autoimmune states.
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source Science Magazine; JSTOR Archival Journals and Primary Sources Collection
subjects B lymphocytes
Dry eye syndromes
Flow velocity
Lymphocytes
Phosphates
Phosphorylation
Rheumatoid arthritis
Saliva
Sjogrens syndrome
Synovial fluid
title Elevated Salivary and Synovial Fluid $\beta _{2}$-Microglobulin in Sjogren's Syndrome and Rheumatoid Arthritis
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