Activation of the pp60c-srcProtein Kinase is an Early Event in Colonic Carcinogenesis

Colonic neoplasia provides an opportunity to study tumor progression because most carcinomas arise from adenomas (polyps), which, in turn, arise from normal epithelia. The malignant potential of adenomas varies with size, histology, and degree of dysplasia. Polyps that are$>$2 cm with villous arc...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1990-01, Vol.87 (2), p.558-562
Main Authors: Cartwright, Christine A., Meisler, Arnold I., Eckhart, Walter
Format: Article
Language:English
Subjects:
Adenoma
Carcinoma
Carcinoma in situ
Crypts
Gels
Histology
Lesions
Mucosa
Phosphorylation
Tumors
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Summary:Colonic neoplasia provides an opportunity to study tumor progression because most carcinomas arise from adenomas (polyps), which, in turn, arise from normal epithelia. The malignant potential of adenomas varies with size, histology, and degree of dysplasia. Polyps that are$>$2 cm with villous architecture and severe dysplasia are most likely to contain carcinoma. Previous studies demonstrated that the in vitro protein-tyrosine kinase activity of pp60c-srcfrom colon carcinomas is significantly higher than that from adjacent normal mucosa. Here we report that the protein kinase activity of pp60c-srcis also elevated in colonic polyps. Activity is highest in malignant polyps and in$>$2-cm benign polyps that contain villous structure and severe dysplasia. Thus, pp60c-srcactivation occurs in benign polyps that are at greatest risk for developing cancer. These data suggest that activation of the protooncogene product pp60c-srcmay be an important event in the genesis of human colon carcinoma.
ISSN:0027-8424