Function of a Human Cyclin Gene as an Oncogene

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-01, Vol.91 (2), p.709-713
Main Authors: Hinds, Philip W., Dowdy, Steven F., Eaton, Elinor Ng, Arnold, Andrew, Weinberg, Robert A.
Format: Article
Language:English
Subjects:
adenovirus
Adenovirus E1A Proteins - genetics
Alleles
Amino Acid Sequence
Animals
Biological and medical sciences
cDNA
Cell Line, Transformed
Cell lines
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Cell Transformation, Neoplastic - genetics
Cells
Cells, Cultured
Cellular biology
Complementary DNA
complementation
Cyclin D1
Cyclins
Cyclins - genetics
Defective Viruses - genetics
E1A gene
Embryonic cells
Fundamental and applied biological sciences. Psychology
Genes
Genes, Viral
Genetic Complementation Test
Humans
man
Molecular and cellular biology
Molecular Sequence Data
Mutation
Oncogene Proteins - genetics
Oncogenes
Plasmids
Rats
Transfection
transformation
Transformed cell line
tumorigenesis
Tumors
Citations: Items that cite this one
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Description
Summary:The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.2.709