Mechanism of wound healing induced by chitosan in streptozotocin diabetic rats

Diabetes mellitus is a common metabolic disorder associated with many pathological conditions. Prolonged or incomplete wound healing is one among them. This is due to poor blood circulation, alterations in circulating constituents, abnormal platelet aggregation and decreased fibrinolytic activity. T...

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Bibliographic Details
Published in:Current science (Bangalore) 1995-09, Vol.69 (5), p.461-464
Main Authors: Naseema, A., Padayatti, Pius S., Paulose, C. S.
Format: Article
Language:English
Subjects:
Aggregation
Agonists
Body weight
Diabetes
Diabetes complications
Diabetes mellitus
Low concentrations
Platelet aggregation
Platelets
RESEARCH COMMUNICATIONS
Wound healing
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Summary:Diabetes mellitus is a common metabolic disorder associated with many pathological conditions. Prolonged or incomplete wound healing is one among them. This is due to poor blood circulation, alterations in circulating constituents, abnormal platelet aggregation and decreased fibrinolytic activity. The aim of the present study was to envisage the role of chitosan in wound healing and to investigate its effect in normalizing the aggregation pattern of platelets in diabetes. At very low concentrations, chitosan has no effect on platelet aggregation, while high concentrations can aggregate the platelets. Chitosan is not capable of reversing the increased rate of aggregation in diabetic platelets. The number of platelets which may affect the normal clotting process were also significantly lower in diabetic rats. Chitosan was found to be a good wound-healing agent, even though it does not reverse the altered platelet aggregation. Chitosan may be enhancing wound healing by some other mechanism independent of its effect on platelet aggregation.
ISSN:0011-3891