Topically applied EGF and PDGFs affect positively the co-ordinate expression of EGF and PDGF receptor genes during acute cutaneous wound-healing process

Daily topical application of epidermal growth factor (EGF) and platelet-derived growth factors (PDGFs) individually resulted in approximately two- to threefold increase in EGF-R and α- and β-PDGF-R mRNA levels, and combinations of these growth factors produced a 2.5 to four-fold increase. Rapid atta...

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Bibliographic Details
Published in:Current science (Bangalore) 2007-03, Vol.92 (5), p.618-627
Main Authors: Gope, Mohan L., Gope, Rajalakshmi
Format: Article
Language:English
Subjects:
Complementary DNA
Diluents
Fibroblast growth factors
Fibroblasts
Healing
Messenger RNA
Receptors
Scars
Topical application
Wound healing
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Summary:Daily topical application of epidermal growth factor (EGF) and platelet-derived growth factors (PDGFs) individually resulted in approximately two- to threefold increase in EGF-R and α- and β-PDGF-R mRNA levels, and combinations of these growth factors produced a 2.5 to four-fold increase. Rapid attainment of maximum level of receptor mRNA on day one and its maintenance at comparatively higher level till day three appears to be essential for faster and better healing. PDGF-AA + EGF inhibited EGF-mediated increase in receptor mRNA levels when applied premixed or within 30 min following EGF application. The results are also suggestive of the possible role of PDGF-AA during later stages of wound healing.
ISSN:0011-3891