Natural Effector T Lymphocytes in Normal Mice

The ``natural'' T-cell activity in normal unimmunized mice was studied. By double-parameter fluorescence-activated cell sorter analysis, it was found that 5-10% of all splenic Lyt-2+and L3T4+lymphocytes are large, of which more than half are in mitotic cycle. In contrast with small resting...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1985-11, Vol.82 (22), p.7691-7695
Main Authors: Pereira, Pablo, Larsson, Eva-Lotta, Forni, Luciana, Bandeira, Antonio, Coutinho, Antonio
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Antibodies
B lymphocytes
Biological and medical sciences
Cell Cycle
Cell growth
Cultured cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immune system
Immunobiology
Immunology
Interleukin-2 - biosynthesis
Lymphocyte Activation
Lymphocytes
Mice
Mice, Inbred BALB C
Organs and cells involved in the immune response
Phenotype
Plasma cells
Rabbits
Spleen - cytology
Spleen cells
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:The ``natural'' T-cell activity in normal unimmunized mice was studied. By double-parameter fluorescence-activated cell sorter analysis, it was found that 5-10% of all splenic Lyt-2+and L3T4+lymphocytes are large, of which more than half are in mitotic cycle. In contrast with small resting cells of the same phenotype, activated (large) T cells isolated from normal mice are functional effector cells: L3T4+large cells induce normal B lymphocytes into proliferation and antibody secretion, while large Lyt-2+cells efficiently suppress B-lymphocyte responses. No effector cell cytolytic activity could be detected among naturally activated T cells. The significance of these findings for the internal activity in the normal immune system is discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.82.22.7691