The 'allosteron' model for entropic allostery of self-assembly

Using the simple 'allosteron' model, we showthat it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive a...

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Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2018-06, Vol.373 (1749), p.1-8
Main Authors: McLeish, Tom, Schaefer, C., von der Heydt, A. C.
Format: Article
Language:English
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Summary:Using the simple 'allosteron' model, we showthat it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue 'Allostery and molecular machines'.
ISSN:0962-8436
1471-2970