Attitudes toward Genetic Research Review: Results from a Survey of Human Genetics Researchers

Background: Researchers often relate personal experiences of difficulties and challenges with Institutional Review Board (IRB) review of their human genetic research protocols. However, there have been no studies that document the range and frequency of these concerns among researchers conducting hu...

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Bibliographic Details
Published in:Community genetics 2011-01, Vol.14 (6), p.337-345
Main Authors: Edwards, K.L., Lemke, A.A., Trinidad, S.B., Lewis, S.M., Starks, H., Griffin, M.T. Quinn, Wiesner, G.L.
Format: Article
Language:English
Subjects:
Attitude
Bioethics
Confidentiality
Data Collection
Ethics Committees, Research
Female
Genetic Research - ethics
Genetics
Genetics - trends
Genomics
Humans
Informed Consent
Male
Original Paper
Polls & surveys
Privacy
Regression Analysis
Research ethics
Research Personnel
Software
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Summary:Background: Researchers often relate personal experiences of difficulties and challenges with Institutional Review Board (IRB) review of their human genetic research protocols. However, there have been no studies that document the range and frequency of these concerns among researchers conducting human genetic/genomic studies. Methods: An online anonymous survey was used to collect information from human genetic researchers regarding views about IRB review of genetic protocols. Logistic regression was used to test specific hypotheses. Results from the national online survey of 351 human genomic researchers are summarized in this report. Results: Issues involving considerable discussion with IRBs included reconsent of subjects (51%), protection of participants’ personal information (39%) and return of results to participants (34%). Over half of the participants had experienced one or more negative consequences of the IRB review process and approximately 25% had experienced one or more positive consequences. Respondents who had served on an IRB were about 80% more likely to report positive consequences of IRB review than their colleagues who had never served on an IRB (p = 0.03). Survey responses were mixed on the need for reconsent before data sharing and risks related to participant reidentification from genomic data. Conclusion: The results from this study provide important perspectives of researchers regarding genetic research review and show lack of consensus on key research ethics issues in genomic research.
ISSN:1662-4246
1662-8063
DOI:10.1159/000324931