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Factors Associated with Participation in Providing Buccal Cell DNA for a Genetic Epidemiologic Study
Aims: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal...
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Published in: | Community genetics 2011-01, Vol.14 (3), p.127-134 |
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description | Aims: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. Results: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≧3 µg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) ( |
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Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. Results: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≧3 µg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (<18.5 kg/m 2 ), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. Conclusions: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.</description><identifier>ISSN: 1662-4246</identifier><identifier>EISSN: 1662-8063</identifier><identifier>DOI: 10.1159/000318808</identifier><identifier>PMID: 20926846</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Blood Pressure ; Body Mass Index ; Cholesterol - blood ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Female ; Genetics ; Health Status Indicators ; Humans ; Life Style ; Male ; Middle Aged ; Molecular Epidemiology ; Mouth Mucosa - metabolism ; Original Paper ; Prospective Studies ; Republic of Korea - epidemiology</subject><ispartof>Community genetics, 2011-01, Vol.14 (3), p.127-134</ispartof><rights>Copyright © 2010 S. Karger AG, Basel</rights><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-1eb93f1f206c33d042fb060e13b7e6ac89a768dc282cddc9080e826281b30cdb3</citedby><cites>FETCH-LOGICAL-c354t-1eb93f1f206c33d042fb060e13b7e6ac89a768dc282cddc9080e826281b30cdb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26776992$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26776992$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,58216,58449</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20926846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, D.R.</creatorcontrib><creatorcontrib>Kim, C.</creatorcontrib><creatorcontrib>Hur, N.W.</creatorcontrib><creatorcontrib>Shim, J.S.</creatorcontrib><creatorcontrib>Shin, S.C.</creatorcontrib><creatorcontrib>Suh, I.</creatorcontrib><title>Factors Associated with Participation in Providing Buccal Cell DNA for a Genetic Epidemiologic Study</title><title>Community genetics</title><addtitle>Public Health Genomics</addtitle><description>Aims: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. Results: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≧3 µg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (<18.5 kg/m 2 ), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. Conclusions: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.</description><subject>Adult</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cholesterol - blood</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Female</subject><subject>Genetics</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Mouth Mucosa - metabolism</subject><subject>Original Paper</subject><subject>Prospective Studies</subject><subject>Republic of Korea - epidemiology</subject><issn>1662-4246</issn><issn>1662-8063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpdkc1PGzEQxS1UBBQ49N5WVi-IQ2Bsb2btY0j5khAgAeeV1_amTjfrYO-C-O9rlJBKnGZG83ujpzeEfGNwwthYnQKAYFKC3CJ7DJGPJKD4su4LXuAu-ZrSHAALBNwhuxwUR1ngHrEX2vQhJjpJKRive2fpq-__0Hsde2_8Uvc-dNR39D6GF299N6NngzG6pVPXtvT37YQ2IVJNL13nsoKeL711Cx_aMMvTQz_YtwOy3eg2ucN13SdPF-eP06vRzd3l9XRyMzJiXPQj5molGtZwQCOEhYI3NSA4JurSoTZS6RKlNVxyY61RIMFJjlyyWoCxtdgnR6u7yxieB5f6auGTyTZ158KQKollUcpS8Uz--kTOwxC7bK5SY1BCqrHM0PEKMjGkFF1TLaNf6PhWMajeg682wWf25_rgUC-c3ZAfSWfg-wr4q-PMxQ2w0f9Yrecpv-O_HMsSVTb8DzE6jxs</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Kang, D.R.</creator><creator>Kim, C.</creator><creator>Hur, N.W.</creator><creator>Shim, J.S.</creator><creator>Shin, S.C.</creator><creator>Suh, I.</creator><general>S. 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Kim, C. ; Hur, N.W. ; Shim, J.S. ; Shin, S.C. ; Suh, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-1eb93f1f206c33d042fb060e13b7e6ac89a768dc282cddc9080e826281b30cdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cholesterol - blood</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>Female</topic><topic>Genetics</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Mouth Mucosa - metabolism</topic><topic>Original Paper</topic><topic>Prospective Studies</topic><topic>Republic of Korea - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, D.R.</creatorcontrib><creatorcontrib>Kim, C.</creatorcontrib><creatorcontrib>Hur, N.W.</creatorcontrib><creatorcontrib>Shim, J.S.</creatorcontrib><creatorcontrib>Shin, S.C.</creatorcontrib><creatorcontrib>Suh, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Community genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, D.R.</au><au>Kim, C.</au><au>Hur, N.W.</au><au>Shim, J.S.</au><au>Shin, S.C.</au><au>Suh, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated with Participation in Providing Buccal Cell DNA for a Genetic Epidemiologic Study</atitle><jtitle>Community genetics</jtitle><addtitle>Public Health Genomics</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>14</volume><issue>3</issue><spage>127</spage><epage>134</epage><pages>127-134</pages><issn>1662-4246</issn><eissn>1662-8063</eissn><abstract>Aims: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. Results: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≧3 µg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (<18.5 kg/m 2 ), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. Conclusions: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>20926846</pmid><doi>10.1159/000318808</doi><tpages>8</tpages></addata></record> |
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subjects | Adult Blood Pressure Body Mass Index Cholesterol - blood Deoxyribonucleic acid DNA DNA - genetics Female Genetics Health Status Indicators Humans Life Style Male Middle Aged Molecular Epidemiology Mouth Mucosa - metabolism Original Paper Prospective Studies Republic of Korea - epidemiology |
title | Factors Associated with Participation in Providing Buccal Cell DNA for a Genetic Epidemiologic Study |
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