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Factors Associated with Participation in Providing Buccal Cell DNA for a Genetic Epidemiologic Study

Aims: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal...

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Published in:Community genetics 2011-01, Vol.14 (3), p.127-134
Main Authors: Kang, D.R., Kim, C., Hur, N.W., Shim, J.S., Shin, S.C., Suh, I.
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creator Kang, D.R.
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Hur, N.W.
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description Aims: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. Results: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≧3 µg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (
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Methods: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. Results: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≧3 µg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (&lt;18.5 kg/m 2 ), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. Conclusions: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.</description><identifier>ISSN: 1662-4246</identifier><identifier>EISSN: 1662-8063</identifier><identifier>DOI: 10.1159/000318808</identifier><identifier>PMID: 20926846</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Blood Pressure ; Body Mass Index ; Cholesterol - blood ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Female ; Genetics ; Health Status Indicators ; Humans ; Life Style ; Male ; Middle Aged ; Molecular Epidemiology ; Mouth Mucosa - metabolism ; Original Paper ; Prospective Studies ; Republic of Korea - epidemiology</subject><ispartof>Community genetics, 2011-01, Vol.14 (3), p.127-134</ispartof><rights>Copyright © 2010 S. Karger AG, Basel</rights><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. 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subjects Adult
Blood Pressure
Body Mass Index
Cholesterol - blood
Deoxyribonucleic acid
DNA
DNA - genetics
Female
Genetics
Health Status Indicators
Humans
Life Style
Male
Middle Aged
Molecular Epidemiology
Mouth Mucosa - metabolism
Original Paper
Prospective Studies
Republic of Korea - epidemiology
title Factors Associated with Participation in Providing Buccal Cell DNA for a Genetic Epidemiologic Study
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