Chemical Composition of the Active Principle of Tuberculin: XVI. Local Cutaneous Sensitization (Arthus' Phenomenon) Produced in Normal Rabbits and Guinea-Pigs by the Protein of Tuberculin

Specific cutaneous sensitization can be produced in normal rabbits and guinea-pigs by repeated injections of the highly purified, undenatured protein of tuberculin. This sensitization is of as high degree and is of the same type as that produced by infection with live tubercle bacilli or by injectio...

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Bibliographic Details
Published in:The Journal of infectious diseases 1932-11, Vol.51 (3), p.383-406
Main Author: Seibert, Florence B.
Format: Article
Language:English
Subjects:
Albumins
Antigens
Arthus reaction
Bacillus
Edema
Eggs
Necrosis
Sensitization
Testes
Tuberculin
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Summary:Specific cutaneous sensitization can be produced in normal rabbits and guinea-pigs by repeated injections of the highly purified, undenatured protein of tuberculin. This sensitization is of as high degree and is of the same type as that produced by infection with live tubercle bacilli or by injection of dead bacilli. The most successful methods for preparing and purifying the protein of tuberculin in such a way as to preserve its antigenic capacity were precipitation by means of ammonium sulphate or trichloro-acetic acid, or merely concentration and washing by means of ultrafiltration.
ISSN:0022-1899