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Human T-Cell Lymphotropic Virus IIIB Glycoprotein (gp120) Bound to CD4 Determinants on Normal Lymphocytes and Expressed by Infected Cells Serves as Target for Immune Attack

The lymphocyte differentiation antigen CD4 serves as a receptor for human retroviruses associated with acquired immunodeficiency syndrome (AIDS) through its interaction with the major envelope virion glycoprotein, gp120, which is also expressed on the surface of infected cells. In these experiments,...

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Published in:Proceedings of the National Academy of Sciences - PNAS 1987-07, Vol.84 (13), p.4601-4605
Main Authors: Lyerly, H. Kim, Matthews, Thomas J., Langlois, Alphonse J., Bolognesi, Dani P., Weinhold, Kent J.
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container_issue 13
container_start_page 4601
container_title Proceedings of the National Academy of Sciences - PNAS
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creator Lyerly, H. Kim
Matthews, Thomas J.
Langlois, Alphonse J.
Bolognesi, Dani P.
Weinhold, Kent J.
description The lymphocyte differentiation antigen CD4 serves as a receptor for human retroviruses associated with acquired immunodeficiency syndrome (AIDS) through its interaction with the major envelope virion glycoprotein, gp120, which is also expressed on the surface of infected cells. In these experiments, purified gp120 was shown to bind to normal human T-lymphocyte populations. The gp120-CD4 complex served as a target antigen for antibody-dependent complement-mediated cytolysis by a goat serum raised against native gp120. However, patient sera that bound to gp120-adsorbed cells failed to direct their destruction in the presence of complement. In contrast, these sera were potent mediators of antibody-dependent cellular cytotoxicity. These studies demonstrate that gp120 situated on the cell surface can serve as an effective target for immune destruction by patient antibodies and effector lymphocytes. The possible contribution of this type of immunity to control of disease progression, on the one hand, and to lymphocyte destruction and immunopathology observed in AIDS, on the other, is discussed.
doi_str_mv 10.1073/pnas.84.13.4601
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Kim</au><au>Matthews, Thomas J.</au><au>Langlois, Alphonse J.</au><au>Bolognesi, Dani P.</au><au>Weinhold, Kent J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human T-Cell Lymphotropic Virus IIIB Glycoprotein (gp120) Bound to CD4 Determinants on Normal Lymphocytes and Expressed by Infected Cells Serves as Target for Immune Attack</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-07-01</date><risdate>1987</risdate><volume>84</volume><issue>13</issue><spage>4601</spage><epage>4605</epage><pages>4601-4605</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The lymphocyte differentiation antigen CD4 serves as a receptor for human retroviruses associated with acquired immunodeficiency syndrome (AIDS) through its interaction with the major envelope virion glycoprotein, gp120, which is also expressed on the surface of infected cells. 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identifier ISSN: 0027-8424
ispartof Proceedings of the National Academy of Sciences - PNAS, 1987-07, Vol.84 (13), p.4601-4605
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source PMC (PubMed Central); JSTOR Archival Journals and Primary Sources Collection
subjects Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - pathology
AIDS
AIDS/HIV
Antibodies
Antibodies, Monoclonal - immunology
Antibodies, Viral - immunology
Antibody dependent cell cytotoxicity
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface - immunology
Antigens, Surface - metabolism
Biological and medical sciences
Cell lines
Complement System Proteins - immunology
Cytotoxicity, Immunologic
Epitopes
Fundamental and applied biological sciences. Psychology
Giant cells
Glycoproteins
HIV - immunology
HIV Envelope Protein gp120
Humans
Lymphocytes
Microbiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Retroviridae Proteins - immunology
Retroviridae Proteins - metabolism
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
T-Lymphocytes - pathology
Virology
Viruses
title Human T-Cell Lymphotropic Virus IIIB Glycoprotein (gp120) Bound to CD4 Determinants on Normal Lymphocytes and Expressed by Infected Cells Serves as Target for Immune Attack
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