A Large Family of Bacterial Activator Proteins

At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB; Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other genes. Based on...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1988-09, Vol.85 (18), p.6602-6606
Main Authors: Henikoff, Steven, Haughn, George W., Calvo, Joseph M., Wallace, James C.
Format: Article
Language:English
Subjects:
Amino acids
Bacterial Proteins - analysis
Bacterial Proteins - genetics
Base Sequence
Biochemistry
DNA
DNA, Bacterial - analysis
DNA, Bacterial - metabolism
Enterobacteriaceae - analysis
Family members
Information Systems
Lod score
Molecular Sequence Data
Nucleic acids
Open reading frames
Operons
Reading frames
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Summary:At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB; Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other genes. Based on sequence alignments, each member of this family is predicted to have a helix-turn-helix DNA binding motif near its amino terminus. The combined evidence indicates that all nine proteins are related by common ancestry, are similarly folded, and are not detectably related to other known bacterial regulatory proteins. The DNA database searching procedure and other methods used in this study should be useful in detecting other groups of related proteins.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.85.18.6602