Loading…
CX_{3}CR1-Mediated$Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokin...
Saved in:
Published in: | Science (American Association for the Advancement of Science) 2005-01, Vol.307 (5707), p.254-258 |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor$CX_{3}CR1$to form transepithelial dendrites, which enable the cells to directly sample luminal antigens.$CX_{3}CR1$was also found to control the clearance of entero-invasive pathogens by DCs. Thus,$CX_{3}CR1-dependent$processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation. |
---|---|
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.1102901 |