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CX_{3}CR1-Mediated$Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokin...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-01, Vol.307 (5707), p.254-258
Main Authors: Niess, Jan Hendrik, Brand, Stephan, Gu, Xiubin, Landsman, Limor, Jung, Steffen, McCormick, Beth A., Vyas, Jatin M., Boes, Marianne, Ploegh, Hidde L., Fox, James G., Littman, Dan R., Reinecker, Hans-Christian
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Language:English
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Summary:Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor$CX_{3}CR1$to form transepithelial dendrites, which enable the cells to directly sample luminal antigens.$CX_{3}CR1$was also found to control the clearance of entero-invasive pathogens by DCs. Thus,$CX_{3}CR1-dependent$processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1102901