Detection of Nonnucleoside Reverse-Transcriptase Inhibitor-Resistant HIV-1 after Discontinuation of VirologicaUy Suppressive Antiretroviral Therapy

Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reversetranscriptase inhibitor-containing antiretroviral therapy. Resistance was...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-08, Vol.47 (3), p.421-424
Main Authors: Hare, C. Bradley, Mellors, John, Krambrink, Amy, Su, Zhaohui, Skiest, Daniel, Margolis, David M., Patel, Sheran S., Barnas, Douglas, Frenkel, Lisa, Coombs, Robert W., Aweeka, Francesca, Morse, Gene D., Haas, David W., Boltz, Valerie, Palmer, Sarah, Coffin, John, Havlir, Diane V.
Format: Article
Language:English
Subjects:
AIDS
Antiretrovirals
Blood plasma
Drug resistance
Genetic mutation
HIV 1
HIV/AIDS
Reverse transcriptase inhibitors
RNA
Sequencing
Virology
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Summary:Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reversetranscriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and ^ 50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.
ISSN:1058-4838
DOI:10.1086/589867