Biophysical model for gamma rhythms in the olfactory bulb via subthreshold oscillations

Gamma oscillations in the olfactory bulb can be produced as an interaction of subthreshold oscillations (STOs) in the mitral cells (MCs) with inhibitory granule cells (GCs). The mechanism does not require that the GCs spike, and we work in a regime in which the MCs fire at rates lower than the fast...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (51), p.21954-21959
Main Authors: Brea, Jorge N, Kay, Leslie M, Kopell, Nancy J
Format: Article
Language:English
Subjects:
Action Potentials
Behavioral neuroscience
Biological Sciences
Biophysics
Cells
Cytoplasmic Granules - physiology
Electric potential
Frequencies
Interneurons
Neural networks
Neurons
Odors
Olfactory bulb
Olfactory Bulb - physiology
Population dynamics
Pyramidal cells
Synapses
Time constants
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Summary:Gamma oscillations in the olfactory bulb can be produced as an interaction of subthreshold oscillations (STOs) in the mitral cells (MCs) with inhibitory granule cells (GCs). The mechanism does not require that the GCs spike, and we work in a regime in which the MCs fire at rates lower than the fast gamma rhythm they create. The frequency of the network is that of the STOs, allowing the gamma to be modulated in amplitude with only small changes in frequency. Gamma oscillations could also be obtained with spiking GCs, but only for GCs firing close to population rate. Our mechanism differs from the more standard description of the gamma oscillation, in which the the decay time of the inhibitory cells is critical to the frequency of the network.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0910964106