Guidelines for Preventing Opportunistic Infections Among Hematopoietic Stem Cell Transplant Recipients: Recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation

CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation have cosponsored these guidelines for preventing opportunistic infections (Ols) among hematopoietic stem cell transplant (HSCT) recipients. The guidelines were drafted with the assistance of...

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Bibliographic Details
Published in:MMWR. Recommendations and reports 2000-10, Vol.49 (RR-10), p.i-125
Main Authors: Dykewicz, Clare A., Jaffe, Harold W., Kaplan, Jonathan E.
Format: Article
Language:English
Subjects:
Blood
Bone marrow
Dosage
Health care administration
Infections
Pediatrics
Preventive medicine
Recommendations
Transplantation
Vaccination
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Summary:CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation have cosponsored these guidelines for preventing opportunistic infections (Ols) among hematopoietic stem cell transplant (HSCT) recipients. The guidelines were drafted with the assistance of a working group of experts in infectious diseases, transplantation, and public health. For the purposes of this report, HSCT is defined as any transplantation of blood-or marrow-derived hematopoietic stem cells, regardless of transplant type (i.e., allogeneic or autologous) or cell source (i.e., bone marrow, peripheral blood, or placental or umbilical cord blood). Such Ols as bacterial, viral, fungal, protozoa!, and helminth infections occur with increased frequency or severity among HSCT recipients. These evidence-based guidelines contain information regarding preventing Ols, hospital infection control, strategies for safe living after transplantation, vaccinations, and hematopoietic stem cell safety. The diseasespecific sections address preventing exposure and disease for pediatrie and adult and autologous and allogeneic HSCT recipients. The goal of these guidelines is twofold: to summarize current data and provide evidence-based recommendations regarding preventing Ols among HSCT patients. The guidelines were developed for use by HSCT recipients, their household and close contacts, transplant and infectious diseases physicians, HSCT center personnel, and public health professionals. For all recommendations, prevention strategies are rated by the strength of the recommendation and the quality of the evidence supporting the recommendation. Adhering to these guidelines should reduce the number and severity of Ols among HSCT recipients.
ISSN:1057-5987
1545-8601