Natural and Unnatural Answers to Evolutionary Questions

Two experiments that revealed natural and unnatural answers to evolutionary questions are described. Depending on assay conditions and interpretations, unnatural sequences may function worse than, as well as, or better than wild type sequences.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-07, Vol.94 (14), p.7126-7128
Main Authors: Conrad, Richard C., Symensma, Tonia L., Ellington, Andrew D.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biology
Biopolymers - chemistry
Biopolymers - genetics
Codons
Commentary
Evolution
Evolution, Molecular
Genetic mutation
Humans
Messenger RNA
Opal
Proteins
Randomness
RNA
Transfer RNA
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Description
Summary:Two experiments that revealed natural and unnatural answers to evolutionary questions are described. Depending on assay conditions and interpretations, unnatural sequences may function worse than, as well as, or better than wild type sequences.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.14.7126