Some Considerations for the Design of Microarray Experiments

Issues relevant for the design of gene expression experiments using spotted cDNA microarrays and gene chip microarrays are overviewed. Emphasis is placed on the uses of replication, and on the importance of identifying major sources of variation.

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Bibliographic Details
Published in:Lecture notes-monograph series 2003-01, Vol.40, p.367-390
Main Authors: Maindonald, John H., Yvonne E. Pittelkow, Wilson, Susan R.
Format: Article
Language:English
Subjects:
Complementary DNA
Dyes
Experiment design
Experimental replication
Gene expression
Genes
Genetic variation
Messenger RNA
Microarrays
Oligonucleotides
RNA
Online Access:Get full text
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Description
Summary:Issues relevant for the design of gene expression experiments using spotted cDNA microarrays and gene chip microarrays are overviewed. Emphasis is placed on the uses of replication, and on the importance of identifying major sources of variation.
ISSN:0749-2170