METHYL GREEN BASOPHILIA OF MATURE AND AGED RAT HEPATOCYTE NUCLEI

Microspectrophotometric analysis of methyl green stained hepatocyte nuclei reveal increased basophilia in cells of senescent rats. Comparison with Feulgen stained hepatocytes eliminates changes in DNA content as an explanation of these findings and offers additional support for the hypothesis that t...

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Bibliographic Details
Published in:Proceedings of the Pennsylvania Academy of Science 1972-12, Vol.46, p.63-65
Main Authors: Grove, Gary L., Mitchell, R. B.
Format: Article
Language:English
Subjects:
BIOLOGY
Cell nucleus
Cellular metabolism
Cellular senescence
Chromatin
DNA
Dyes
Hepatocytes
Histograms
Hydrolysis
Liver
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Summary:Microspectrophotometric analysis of methyl green stained hepatocyte nuclei reveal increased basophilia in cells of senescent rats. Comparison with Feulgen stained hepatocytes eliminates changes in DNA content as an explanation of these findings and offers additional support for the hypothesis that this reflects an increased metabolic state. It is suggested that this functional alteration is compensatory for the loss of cells which occurs with advancing age.
ISSN:0096-9222